Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4759176 | 0.89 | MAPK14 (0.36) | MAPK14NQO2MAOBNFE2L2 | |
| SCHEMBL4772006 | 0.80 | TP53 (0.34) | MAPK14NPC1GAARAB9ASMN1; SMN2 | |
| SCHEMBL4964977 | 0.79 | TDP2 (0.33) | TDP2 | |
| SCHEMBL4713338 | 0.77 | GPBAR1 (0.34) | TDP2 | |
| SCHEMBL4596623 | 0.76 | MAPK14 (0.40) | MAPK14MAOBHTR2A | |
| SCHEMBL4760683 | 0.76 | CA12 (0.41) | TDP2NPC1GAARAB9ASMN1; SMN2 | |
| SCHEMBL4596617 | 0.75 | MAPK14 (0.39) | MAPK14NQO2AMY1AMAOBGAA | |
| SCHEMBL4768176 | 0.75 | PTGS2 (0.39) | TDP2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5595895 | 0.75 | MAPT (0.38) | NPC1GAARAB9ASMN1; SMN2 | |
| SCHEMBL5605458 | 0.74 | MAPK14 (0.38) | MAPK14AMY1AMAOBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871356-A1 | DIHYDROBENZOFURAN DERIVATIVES AND USES THEREOF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-02 | — | — | EP | disclosed |
| EP-1871354-A1 | TREATMENT OF PAIN | Wyeth (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006116170-A1 | DIHYDROBENZOFURAN DERIVATIVES AND USES THEREOF | WYETH (US) | 2006-11-02 | — | — | WO | disclosed |
| WO-2006116171-A1 | TREATMENT OF PAIN | WYETH (US) | 2006-11-02 | — | — | WO | disclosed |