Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.36 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | PLG | P00747 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8437618 | 0.85 | MEN1 (0.48) | MEN1KMT2APOLB | |
| SCHEMBL14717867 | 0.73 | POLB (0.58) | MEN1KMT2APOLBSLC22A1PRCP | |
| SCHEMBL17542064 | 0.69 | POLB (0.71) | POLBGBA1PLG | |
| SCHEMBL17542062 | 0.69 | POLB (0.71) | POLBGBA1PLG | |
| SCHEMBL3124097 | 0.68 | PNMT (0.62) | MEN1KMT2APOLBPRCP | |
| SCHEMBL4828422 | 0.68 | POLB (0.44) | MEN1KMT2APOLBSLC22A1PRCP | |
| Hydrochloric Acid SCHEMBL17542000 | 0.67 | POLB (0.69) | MEN1KMT2APOLBGBA1PLG | |
| Hydrochloric Acid SCHEMBL18862980 | 0.67 | POLB (0.69) | MEN1KMT2APOLBGBA1PLG | |
| SCHEMBL14933982 | 0.66 | MEN1 (0.52) | MEN1KMT2APOLB | |
| SCHEMBL14732785 | 0.66 | MEN1 (0.52) | MEN1KMT2APOLBSLC22A1PRCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004625-A2 | C-MET PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | Vertex Pharmaceuticals Incorporated (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007111904-A2 | C-MET PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-04 | — | — | WO | disclosed |