Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.35 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4594197 | 0.74 | POLB (0.40) | POLBMEN1KMT2A | |
| SCHEMBL14717867 | 0.69 | POLB (0.58) | POLBMEN1KMT2ASLC22A1PRCP | |
| SCHEMBL4768294 | 0.68 | MEN1 (0.46) | POLBMEN1KMT2ASLC22A1PRCP | |
| SCHEMBL17542062 | 0.68 | POLB (0.71) | POLBGBA1 | |
| SCHEMBL17542064 | 0.68 | POLB (0.71) | POLBGBA1 | |
| Hydrochloric Acid SCHEMBL17542000 | 0.66 | POLB (0.69) | POLBMEN1KMT2AGBA1 | |
| Hydrochloric Acid SCHEMBL18862980 | 0.66 | POLB (0.69) | POLBMEN1KMT2AGBA1 | |
| SCHEMBL10684249 | 0.65 | MTNR1A (0.50) | POLBMEN1KMT2ASLC22A1PRCP | |
| SCHEMBL3124097 | 0.64 | PNMT (0.62) | POLBMEN1KMT2APRCP | |
| SCHEMBL6965238 | 0.64 | POLB (0.47) | POLBGBA1DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899350-A1 | PYRAZOLO Ý3 , 4-D¨AZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007025596-A1 | PYRAZOLO [3 , 4-D] AZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2007-03-08 | — | — | WO | disclosed |