Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.53 |
| ▸ | RELA | Q04206 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4770267 | 0.94 | HRH3 (0.57) | HRH3NPC1NFKB1HTTRAB9A | |
| SCHEMBL4774646 | 0.92 | HRH3 (0.67) | HRH3NPC1NFKB1HTTRAB9A | |
| SCHEMBL4773028 | 0.89 | RAB9A (0.60) | HRH3NPC1NFKB1RAB9ANFKB2 | |
| Trifluoroacetic Acid SCHEMBL4765533 | 0.87 | HRH3 (0.61) | HRH3NPC1NFKB1HTTRAB9A | |
| Trifluoroacetic Acid SCHEMBL4770822 | 0.85 | RAB9A (0.53) | HRH3NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL4777053 | 0.84 | HRH3 (0.57) | HRH3NPC1NFKB1HTTRAB9A | |
| SCHEMBL4767344 | 0.83 | TDP1 (0.58) | HRH3NPC1NFKB1HTTRAB9A | |
| SCHEMBL4774628 | 0.83 | TMPRSS2 (0.61) | HRH3NPC1NFKB1HTTRAB9A | |
| SCHEMBL4772670 | 0.83 | NPC1 (0.71) | NPC1NFKB1HTTRAB9ANFKB2 | |
| SCHEMBL4772154 | 0.83 | NPC1 (0.52) | HRH3NPC1NFKB1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | claimed |