Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SCD | O00767 | 1/20 | 0.32 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.30 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4770647 | 1.00 | ADORA2A (0.33) | ADORA2AADORA2BADORA1MAPTALDH1A1 | |
| SCHEMBL4766042 | 0.95 | ALDH1A1 (0.35) | ADORA2AADORA2BADORA1MAPTALDH1A1 | |
| SCHEMBL4766036 | 0.95 | ALDH1A1 (0.35) | ADORA2AADORA2BADORA1MAPTALDH1A1 | |
| SCHEMBL4762596 | 0.93 | MAPT (0.37) | ADORA2AADORA2BADORA1MAPTALDH1A1 | |
| SCHEMBL4762591 | 0.93 | MAPT (0.37) | ADORA2AADORA2BADORA1MAPTALDH1A1 | |
| SCHEMBL4763634 | 0.91 | ADORA2A (0.35) | ADORA2AADORA2BADORA1ALDH1A1SCD | |
| SCHEMBL4763642 | 0.91 | ADORA2A (0.35) | ADORA2AADORA2BADORA1ALDH1A1SCD | |
| SCHEMBL4794079 | 0.90 | MAPT (0.38) | ADORA2AADORA2BADORA1MAPTALDH1A1 | |
| SCHEMBL4794085 | 0.90 | MAPT (0.38) | ADORA2AADORA2BADORA1MAPTALDH1A1 | |
| SCHEMBL4767385 | 0.86 | ADORA2B (0.38) | ADORA2AADORA2BADORA1ALDH1A1SCD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678181-B1 | A2B ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS INC (US) | 2008-12-31 | — | — | EP | disclosed |