Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GNRHR | P30968 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4794079 | 1.00 | MAPT (0.38) | MAPTALDH1A1MAPK1ADORA2AADORA2B | |
| SCHEMBL4767823 | 0.94 | MAPT (0.42) | MAPTALDH1A1MAPK1ADORA2AADORA2B | |
| SCHEMBL4767816 | 0.94 | MAPT (0.42) | MAPTALDH1A1MAPK1ADORA2AADORA2B | |
| SCHEMBL4762383 | 0.93 | MAPT (0.42) | MAPTALDH1A1MAPK1ADORA2AADORA2B | |
| SCHEMBL4766036 | 0.93 | ALDH1A1 (0.35) | MAPTALDH1A1ADORA2AADORA2BADORA1 | |
| SCHEMBL4766042 | 0.93 | ALDH1A1 (0.35) | MAPTALDH1A1ADORA2AADORA2BADORA1 | |
| SCHEMBL4791799 | 0.92 | NPBWR1 (0.40) | MAPTALDH1A1MAPK1ADORA2AADORA2B | |
| SCHEMBL4791802 | 0.92 | NPBWR1 (0.40) | MAPTALDH1A1MAPK1ADORA2AADORA2B | |
| SCHEMBL4770638 | 0.90 | ADORA2A (0.33) | MAPTALDH1A1ADORA2AADORA2BADORA1 | |
| SCHEMBL4770647 | 0.90 | ADORA2A (0.33) | MAPTALDH1A1ADORA2AADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678181-B1 | A2B ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS INC (US) | 2008-12-31 | — | — | EP | disclosed |