Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.47 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.47 |
| ▸ | INMT | O95050 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL27628514 | 0.89 | TSHR (0.53) | TSHRTP53EGLN1EGLN3INMT | |
| Bicarbonate SCHEMBL5594325 | 0.83 | ALDH1A1 (0.43) | GAAHTTSMN1; SMN2ALDH1A1 | |
| Acrylic Acid SCHEMBL29185437 | 0.82 | LMNA (0.50) | SMN1; SMN2ALDH1A1 | |
| Maleic Acid SCHEMBL10749964 | 0.80 | TSHR (0.75) | TSHRTP53EGLN1EGLN3INMT | |
| Fumaric Acid SCHEMBL18586002 | 0.80 | TSHR (0.75) | TSHRTP53EGLN1EGLN3INMT | |
| Fumaric Acid SCHEMBL4771229 | 0.78 | TSHR (0.53) | TSHRTP53EGLN1EGLN3INMT | |
| Carbamic Acid SCHEMBL28889871 | 0.78 | ACHE (0.41) | GAANPC1SMN1; SMN2ALDH1A1 | |
| Acetic Acid SCHEMBL29101711 | 0.78 | FFAR3 (0.41) | GAAHTTSMN1; SMN2ALDH1A1 | |
| Maleic Acid SCHEMBL31167986 | 0.78 | TSHR (0.53) | TSHRTP53EGLN1EGLN3INMT | |
| Fumaric Acid SCHEMBL4771239 | 0.78 | TSHR (0.53) | TSHRTP53EGLN1EGLN3INMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102225046-A | Transdermal drug delivery formulation | NUVO RES INC | 2011-10-26 | — | — | CN | disclosed |
| CN-101296691-B | Transdermal drug delivery dosage form | NUVO RES INC | 2011-07-27 | — | — | CN | disclosed |
| CN-101296691-A | transdermal drug delivery dosage form | NUVO RES INC (CA) | 2008-10-29 | — | — | CN | disclosed |