Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I3 | Q14994 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 5/20 | 0.45 |
| ▸ | DRD2 | P14416 | 5/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | NAMPT | P43490 | 3/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3527537 | 0.88 | NAMPT (0.53) | NR1I3DRD2NAMPTTLR9TLR8 | |
| SCHEMBL26666903 | 0.82 | DRD2 (0.55) | DRD2DRD3 | |
| SCHEMBL31671046 | 0.82 | DRD2 (0.55) | DRD2DRD3 | |
| SCHEMBL3530164 | 0.80 | TERT (0.43) | NR1I3DRD4DRD2NAMPT | |
| SCHEMBL17920283 | 0.80 | PRKCI (0.48) | NAMPTNPY1R | |
| SCHEMBL27741869 | 0.79 | ACHE (0.45) | DRD4DRD2NAMPTTLR9TLR8 | |
| SCHEMBL28030260 | 0.77 | BTK (0.53) | DRD2NPY1R | |
| SCHEMBL3530693 | 0.77 | TLR9 (0.48) | DRD4DRD2DRD3NAMPTTLR9 | |
| SCHEMBL5190565 | 0.77 | KMO (0.47) | NPY1R | |
| SCHEMBL27741867 | 0.76 | TLR9 (0.41) | DRD2NAMPTTLR9TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937681-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007033232-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-03-22 | — | — | WO | disclosed |