Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SETDB1 | Q15047 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GLS | O94925 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | OGA | O60502 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6936153 | 0.86 | MME (0.48) | MMESMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL8630597 | 0.79 | NPSR1 (0.42) | SMN1; SMN2NPC1RAB9ANPSR1ALOX15 | |
| SCHEMBL22134467 | 0.75 | ALDH1A1 (0.41) | SMN1; SMN2NPC1RAB9ANPSR1ALOX15 | |
| SCHEMBL16373614 | 0.73 | — | — | |
| SCHEMBL4664006 | 0.70 | NPSR1 (0.44) | SMN1; SMN2NPC1RAB9ANPSR1ALOX15 | |
| SCHEMBL2258773 | 0.69 | OGA (0.40) | MMESMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL21452365 | 0.69 | OGA (0.44) | MMESMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL9781931 | 0.68 | F2 (0.62) | SMN1; SMN2NPC1RAB9ATP53L3MBTL1 | |
| SCHEMBL17788454 | 0.68 | TRPM5 (0.38) | MMESMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL4324910 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007717-A1 | NOVEL SULFONAMIDE COMPOUNDS | Actelion Pharmaceuticals Ltd. (CH) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007116374-A1 | NOVEL SULFONAMIDE COMPOUNDS | ACTELION PHARMACEUTICALS LTD (CH) | 2007-10-18 | — | — | WO | disclosed |