Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | VHL | P40337 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9298086 | 0.81 | HDAC6 (0.46) | NPSR1SMN1; SMN2RAB9ANPC1VHL | |
| SCHEMBL9297727 | 0.76 | HDAC6 (0.42) | NPSR1SMN1; SMN2RAB9ANPC1VHL | |
| SCHEMBL6096301 | 0.76 | NPSR1 (0.39) | NPSR1RAB9ANPC1VHLHDAC6 | |
| SCHEMBL2710573 | 0.75 | — | — | |
| SCHEMBL5204666 | 0.74 | ERCC1 (0.47) | SMN1; SMN2TRPM5RAB9ANPC1MEN1 | |
| SCHEMBL8052844 | 0.73 | TRPM5 (0.44) | PDE10ASMN1; SMN2TRPM5RAB9ANPC1 | |
| SCHEMBL3509510 | 0.73 | HDAC6 (0.47) | PDE10ASMN1; SMN2RAB9AGAAKMT2A | |
| SCHEMBL6199061 | 0.72 | SLC6A3 (0.44) | SMN1; SMN2TRPM5RAB9ANPC1GAA | |
| SCHEMBL2259175 | 0.72 | TRPM5 (0.43) | PDE10ASMN1; SMN2TRPM5RAB9ANPC1 | |
| SCHEMBL4961811 | 0.71 | ALDH1A1 (0.44) | NPSR1SMN1; SMN2RAB9ANPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007717-A1 | NOVEL SULFONAMIDE COMPOUNDS | Actelion Pharmaceuticals Ltd. (CH) | 2008-12-31 | — | — | EP | claimed |
| WO-2007116374-A1 | NOVEL SULFONAMIDE COMPOUNDS | ACTELION PHARMACEUTICALS LTD (CH) | 2007-10-18 | — | — | WO | claimed |