Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2884180 | 0.90 | CYP11B2 (0.37) | CYP11B2MEN1KMT2AKDM4EMAPK1 | |
| SCHEMBL2881706 | 0.86 | HRH3 (0.36) | CYP11B2MEN1KMT2AKDM4EMAPK1 | |
| SCHEMBL12995592 | 0.86 | CYP11B2 (0.36) | CYP11B2MEN1KMT2AKDM4EMAPK1 | |
| SCHEMBL13198856 | 0.83 | HRH3 (0.34) | CYP11B2MEN1KMT2AKDM4EMAPK1 | |
| SCHEMBL2884321 | 0.82 | CHEK2 (0.43) | MEN1KMT2AKDM4EALDH1A1HRH3 | |
| SCHEMBL13198734 | 0.81 | PDGFRB (0.41) | MEN1KMT2AMAPK1L3MBTL1TDP1 | |
| SCHEMBL13198744 | 0.81 | ALDH1A1 (0.40) | MEN1KMT2AMAPK1L3MBTL1LMNA | |
| SCHEMBL13198730 | 0.81 | PDGFRB (0.41) | MEN1KMT2AMAPK1L3MBTL1ESR1 | |
| SCHEMBL12995744 | 0.81 | HRH3 (0.44) | MEN1KMT2AMAPTALDH1A1HRH3 | |
| SCHEMBL10096681 | 0.81 | PDGFRB (0.39) | CYP11B2MEN1KMT2AMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984332-A2 | METHODS FOR TREATING HEPATITIS C | PTC Therapeutics, Inc. (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007084413-A2 | METHODS FOR TREATING HEPATITIS C | PTC THERAPEUTICS, INC. (US) | 2007-07-26 | — | — | WO | disclosed |