Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.41 |
| ▸ | RELA | Q04206 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4772037 | 0.95 | SLC2A1 (0.43) | MEN1KMT2AHRH3ROCK1NPC1 | |
| SCHEMBL4770985 | 0.78 | MAP4K1 (0.57) | NPC1RAB9A | |
| SCHEMBL4794145 | 0.78 | MAPT (0.53) | MEN1KMT2AHRH3NPC1NFKB1 | |
| SCHEMBL4768583 | 0.78 | TMPRSS2 (0.62) | MEN1KMT2ANPC1NFKB1RAB9A | |
| SCHEMBL4770392 | 0.78 | HRH3 (0.59) | HRH3NPC1NFKB1RAB9ANFKB2 | |
| SCHEMBL4794584 | 0.77 | MEN1 (0.48) | MEN1KMT2AHRH3SMN1; SMN2HRH1 | |
| SCHEMBL5823896 | 0.77 | HRH3 (0.54) | KMT2AHRH3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4775002 | 0.77 | RAB9A (0.53) | HRH3NPC1NFKB1RAB9ANFKB2 | |
| SCHEMBL4768184 | 0.77 | KMT2A (0.49) | MEN1KMT2AHRH3NPC1NFKB1 | |
| SCHEMBL4793943 | 0.77 | ABCB1 (0.55) | MEN1KMT2AHRH3NPC1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | claimed |