Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8707599 | 0.88 | TSHR (0.39) | TSHRGAAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7484744 | 0.87 | TSHR (0.37) | TSHRGAAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL28460443 | 0.86 | ALDH1A1 (0.38) | TSHRGAAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7481761 | 0.85 | TSHR (0.38) | TSHRGAAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL5844147 | 0.83 | MAPK1 (0.46) | TSHRGAAALDH1A1MAPTMEN1 | |
| SCHEMBL1226544 | 0.80 | KDM4E (0.43) | TSHRGAAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8703625 | 0.78 | TSHR (0.44) | TSHRGAAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL3420317 | 0.78 | AKR1B1 (0.42) | GAAALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL2062770 | 0.77 | ALDH1A1 (0.42) | GAAALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL28798757 | 0.76 | HTT (0.42) | ALDH1A1POLBRAB9AHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462622-B2 | Pyrrolo[2, 3-d] pyrimidine derivatives as corticotropin releasing factor antagonists | GLAXO GROUP LIMITED (GB) | 2008-12-09 | — | — | US | disclosed |
| US-7446108-B2 | Tri-and tetraaza-acenaphthylen derivatives as CRF receptor antagonists | NEUROCRINE, INC. (US) | 2008-11-04 | — | — | US | disclosed |
| EP-1395591-B1 | CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-06-04 | — | — | EP | disclosed |
| EP-1383747-B1 | FUSED PYRIMIDINES AS ANTAGONISTS OF THE CORTICOTROPIN RELEASING FACTOR (CRF) | GLAXO GROUP LTD (GB) | 2008-02-20 | — | — | EP | disclosed |
| US-7329667-B2 | A hexahydro-1,5,6,8-tetraaza-acenaphthylene or -1,3,4-triazaphenalene derivatives; treatment of depression and anxiety; inflammatory bowel disease; treatment of conditions mediated by corticotropin-releasing factor | GLAXO GROUP LIMITED (GB) | 2008-02-12 | — | — | US | disclosed |
| US-7279474-B2 | Substituted pyrrolo[2,3-d]pyrimidines as antagonists of the corticotropin releasing factor (CRF) | GLAXO GROUP LIMITED (GB) | 2007-10-09 | — | — | US | disclosed |
| EP-1392689-B1 | TRI- AND TETRAAZA-ACENAPHTHYLEN DERIVATIVES AS CRF RECEPTOR ANTAGONISTS | NEUROCRINE BIOSCIENCES INC (US) | 2006-10-25 | — | — | EP | disclosed |
| EP-1383498-B1 | CRF RECEPTOR ANTAGONISTS | GLAXO GROUP LTD (GB) | 2006-03-15 | — | — | EP | disclosed |
| US-20040235871-A1 | Crf receptor antagonists | GLAXO GROUP LIMITED (GB) | 2004-11-25 | — | — | US | disclosed |
| US-20040198726-A1 | Tri-and tetraaza-acenaphthylen derivatives as crf receptor antagonists | SMITHKLINE BEECHAM (CORK) LIMITED (IE) | 2004-10-07 | — | — | US | disclosed |
| EP-1392689-A1 | TRI- AND TETRAAZA-ACENAPHTHYLEN DERIVATIVES AS CRF RECEPTOR ANTAGONISTS | Neurocrine Biosciences, Inc. (US) | 2004-03-03 | — | — | EP | disclosed |
| EP-1383747-A1 | FUSED PYRIMIDINES AS ANTAGONISTS OF THE CORTICOTROPIN RELEASING FACTOR (CRF) | GLAXO GROUP LIMITED (GB) | 2004-01-28 | — | — | EP | disclosed |
| WO-2002100863-A1 | CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2002-12-19 | — | — | WO | disclosed |
| WO-2002094826-A1 | TRI-AND TETRAAZA-ACENAPHTHYLEN DERIVATIVES AS CRF RECEPTOR ANTAGONISTS | NEUROCRINE BIOSCIENCES INC. (US) | 2002-11-28 | — | — | WO | disclosed |
| WO-2002088095-A1 | FUSED PYRIMIDINES AS ANTAGONISTS OF THE CORTICOTROPIN RELEASING FACTOR (CRF) | GLAXO GROUP LIMITED (GB) | 2002-11-07 | — | — | WO | disclosed |
| US-5783580-A | FUNGICIDES | SANDOZ, LTD. (CH) | 1998-07-21 | — | — | US | disclosed |
| US-5776941-A | FUNGICIDES | SANDOZ LTD (CH) | 1998-07-07 | — | — | US | disclosed |
| EP-0731095-A1 | 4-Alkylthio-pyrimidin-5-ylacetic acid derivatives | SANDOZ LTD. (CH) | 1996-09-11 | — | — | EP | disclosed |
| US-5547919-A | CONTROLLING PHYTOPATHOGENIC FUNGI | SANDOZ LTD. (CH) | 1996-08-20 | — | — | US | disclosed |
| EP-0667343-A1 | Alpha-pyrimidinyl acrylic acid derivatives with fungicidal activity | SANDOZ LTD. (CH) | 1995-08-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040235871-A1 | Crf receptor antagonists | CRHR1, CRHR2, CRH | TSHR 143/4885GAA 4491/4885ALDH1A1 3620/4885 |
| US-20040198726-A1 | Tri-and tetraaza-acenaphthylen derivatives as crf receptor antagonists | CRHR1, AGTR1, NPY1R | TSHR 64/4885GAA 1171/4885ALDH1A1 1258/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.