Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4767403 | 0.87 | MEN1 (0.44) | MEN1KMT2ATP53PARP1 | |
| SCHEMBL4776971 | 0.80 | MEN1 (0.46) | MAPTMEN1KMT2APARP1GAA | |
| SCHEMBL4775804 | 0.79 | MEN1 (0.46) | MAPTMEN1KMT2APARP1GAA | |
| SCHEMBL4769038 | 0.76 | MEN1 (0.44) | MAPTMEN1KMT2APARP1GAA | |
| SCHEMBL4772481 | 0.76 | MEN1 (0.43) | MAPTPOLBMEN1KMT2ATP53 | |
| SCHEMBL4767193 | 0.75 | TUBB4A (0.43) | MEN1KMT2APARP1 | |
| SCHEMBL4295752 | 0.75 | MEN1 (0.42) | MAPTMEN1KMT2APARP1GAA | |
| SCHEMBL5769122 | 0.74 | MEN1 (0.56) | RXFP1MAPTPOLBL3MBTL1MEN1 | |
| SCHEMBL4772661 | 0.74 | ALDH1A1 (0.44) | MAPTPOLBTDP1MEN1KMT2A | |
| SCHEMBL4776947 | 0.73 | RNASEH1 (0.49) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881988-A1 | 2,3-SUBSTITUTED FUSED BICYCLIC PYRIMIDIN-4(3H)-ONES MODULATING THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) | MERCK SHARP & DOHME LTD. (GB) | 2008-01-30 | — | — | EP | disclosed |
| WO-2006122200-A1 | 2,3-SUBSTITUTED FUSED BICYCLIC PYRIMIDIN-4(3H)-ONES MODULATING THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) | MERCK SHARP & DOHME LIMITED (GB) | 2006-11-16 | — | — | WO | disclosed |