Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 11/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | NFKBIA | P25963 | 2/20 | 0.36 |
| ▸ | RELA | Q04206 | 2/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4768062 | 0.86 | DYRK3 (0.38) | SLC40A1MAPTKDM4EMEN1HSP90AA1 | |
| SCHEMBL2787721 | 0.84 | DYRK3 (0.46) | ADRA2AMCL1MEN1KMT2AL3MBTL1 | |
| SCHEMBL2787724 | 0.84 | DYRK3 (0.46) | ADRA2AMCL1MEN1KMT2AL3MBTL1 | |
| SCHEMBL4774386 | 0.83 | MEN1 (0.49) | NFKBIARELAMAPTNPSR1KDM4E | |
| SCHEMBL4768194 | 0.77 | BACE1 (0.36) | SLC40A1RELAMAPTKDM4EMEN1 | |
| SCHEMBL4770530 | 0.73 | PDE10A (0.46) | SLC40A1NFKBIARELAMAPTMDM2 | |
| SCHEMBL4772146 | 0.73 | DYRK3 (0.54) | MEN1KMT2APOLB | |
| SCHEMBL4775509 | 0.73 | DYRK3 (0.55) | MEN1KMT2APOLB | |
| SCHEMBL4776074 | 0.72 | NPC1 (0.35) | SLC40A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL4775747 | 0.71 | GPR84 (0.38) | SLC40A1MEN1KMT2AL3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567112-B1 | THIAZOLIDIN-4-ONES FOR INHIBITING hYAK3 PROTEINS | SMITHKLINE BEECHAM CORP (US) | 2008-10-15 | — | — | EP | claimed |