Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | NFKBIA | P25963 | 2/20 | 0.39 |
| ▸ | RELA | Q04206 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4768062 | 0.85 | DYRK3 (0.38) | MEN1KMT2AMAPTALDH1A1KDR | |
| SCHEMBL2789830 | 0.85 | MEN1 (0.46) | MEN1KMT2AMAPTALDH1A1RAB9A | |
| SCHEMBL2789825 | 0.85 | MEN1 (0.46) | MEN1KMT2AMAPTALDH1A1RAB9A | |
| SCHEMBL4772929 | 0.83 | SLC40A1 (0.38) | MEN1KMT2AMAPTNFKBIARELA | |
| SCHEMBL4770530 | 0.82 | PDE10A (0.46) | MEN1KMT2AMAPTALDH1A1RAB9A | |
| SCHEMBL2999189 | 0.74 | ALDH1A1 (0.42) | MEN1KMT2AMAPTALDH1A1NFKBIA | |
| SCHEMBL2999185 | 0.74 | ALDH1A1 (0.42) | MEN1KMT2AMAPTALDH1A1NFKBIA | |
| SCHEMBL4768194 | 0.74 | BACE1 (0.36) | MEN1KMT2AMAPTALDH1A1RAB9A | |
| SCHEMBL4775747 | 0.70 | GPR84 (0.38) | MEN1KMT2ARAB9AGAASMN1; SMN2 | |
| SCHEMBL4765880 | 0.70 | ROCK1 (0.43) | MEN1KMT2AMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567112-B1 | THIAZOLIDIN-4-ONES FOR INHIBITING hYAK3 PROTEINS | SMITHKLINE BEECHAM CORP (US) | 2008-10-15 | — | — | EP | claimed |