Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2787658 | 0.83 | DYRK3 (0.48) | NPC1RAB9AKMT2AMAPTALDH1A1 | |
| SCHEMBL2787656 | 0.83 | DYRK3 (0.48) | NPC1RAB9AKMT2AMAPTALDH1A1 | |
| SCHEMBL4768194 | 0.80 | BACE1 (0.36) | NPC1RAB9AKMT2AMAPTALDH1A1 | |
| SCHEMBL4774451 | 0.76 | ALOX5 (0.42) | NPC1RAB9AKMT2AMAPTALDH1A1 | |
| SCHEMBL4765880 | 0.74 | ROCK1 (0.43) | KMT2AMEN1L3MBTL1 | |
| SCHEMBL4770530 | 0.73 | PDE10A (0.46) | NPC1RAB9AKMT2AMAPTALDH1A1 | |
| SCHEMBL4768062 | 0.72 | DYRK3 (0.38) | KMT2AMAPTALDH1A1GLAPOLB | |
| SCHEMBL4772929 | 0.72 | SLC40A1 (0.38) | KMT2AMAPTPOLBSLC40A1MEN1 | |
| SCHEMBL4774422 | 0.71 | CYP2C9 (0.36) | NPC1RAB9AKMT2AMAPTALDH1A1 | |
| SCHEMBL2993506 | 0.71 | CISD1 (0.39) | KMT2AMAPTALDH1A1HTTSLC40A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567112-B1 | THIAZOLIDIN-4-ONES FOR INHIBITING hYAK3 PROTEINS | SMITHKLINE BEECHAM CORP (US) | 2008-10-15 | — | — | EP | claimed |