Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 3/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4517305 | 0.86 | MAOB (0.41) | MEN1KMT2ABRD9CCR1P2RX3 | |
| SCHEMBL4768907 | 0.79 | SMN1; SMN2 (0.34) | MEN1KMT2ABRD9CDK1KDM4E | |
| SCHEMBL4521578 | 0.77 | TP53 (0.42) | MEN1KMT2ACCR1P2RX3CDK1 | |
| SCHEMBL4772467 | 0.77 | MAT2A (0.40) | MEN1KMT2ABRD9ALDH1A1SMN1; SMN2 | |
| SCHEMBL4284448 | 0.74 | NPC1 (0.34) | CDK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4357095 | 0.73 | MAT2A (0.38) | MEN1KMT2ACDK1KDM4EALDH1A1 | |
| SCHEMBL4793975 | 0.73 | KMT2A (0.45) | MEN1KMT2ACDK1SMN1; SMN2MAOA | |
| SCHEMBL4769839 | 0.73 | NPC1 (0.33) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL5768791 | 0.72 | DDR1 (0.37) | ALDH1A1MAOB | |
| SCHEMBL5768045 | 0.70 | PLA2G7 (0.36) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881988-A1 | 2,3-SUBSTITUTED FUSED BICYCLIC PYRIMIDIN-4(3H)-ONES MODULATING THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) | MERCK SHARP & DOHME LTD. (GB) | 2008-01-30 | — | — | EP | disclosed |
| WO-2006122200-A1 | 2,3-SUBSTITUTED FUSED BICYCLIC PYRIMIDIN-4(3H)-ONES MODULATING THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) | MERCK SHARP & DOHME LIMITED (GB) | 2006-11-16 | — | — | WO | disclosed |