Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.57 |
| ▸ | PDK2 | Q15119 | 5/20 | 0.44 |
| ▸ | CCR6 | P51684 | 1/20 | 0.44 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA7 | P43166 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.42 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7502227 | 0.88 | NOTUM (0.46) | NOTUMPDK2CCR6HKDC1CA12 | |
| SCHEMBL29144717 | 0.83 | NOTUM (0.54) | NOTUMCCR6HKDC1CA12CA1 | |
| SCHEMBL2334632 | 0.82 | NOTUM (0.48) | NOTUMPDK2CCR6HKDC1CA12 | |
| SCHEMBL2358109 | 0.82 | NOTUM (0.53) | NOTUMCCR6HKDC1CA12CA1 | |
| SCHEMBL22289088 | 0.82 | SMN1; SMN2 (0.49) | NOTUMHPGDPOLBKDM4EALDH1A1 | |
| SCHEMBL2802208 | 0.82 | NOTUM (0.51) | NOTUMPDK2CCR6HKDC1CA12 | |
| SCHEMBL29715212 | 0.81 | NOTUM (0.51) | NOTUMCCR6HKDC1CA12CA1 | |
| SCHEMBL256770 | 0.81 | NOTUM (0.51) | NOTUMCCR6HKDC1CA12CA1 | |
| SCHEMBL2310555 | 0.81 | P4HB (0.52) | NOTUMCCR6HKDC1CA12CA1 | |
| SCHEMBL18284484 | 0.80 | NOTUM (0.48) | NOTUMPDK2CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063144-B1 | ANTIPARASITIC AND PESTICIDAL ISOXAZOLINE COMPOUNDS | BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC (US) | 2021-09-08 | — | — | EP | disclosed |
| EP-3063144-B1 | ANTIPARASITIC AND PESTICIDAL ISOXAZOLINE COMPOUNDS | BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC (US) | 2021-09-08 | — | — | EP | disclosed |
| EP-3733664-A1 | ANTIPARISITIC AND PESTICIDAL ISOXAZOLINE COMPOUNDS | Boehringer Ingelheim Animal Health USA Inc. (US) | 2020-11-04 | — | — | EP | disclosed |
| US-9447084-B2 | Antiparisitic and pesticidal isoxazoline compounds | MERIAL, INC. (US) | 2016-09-20 | — | — | US | disclosed |
| US-9447084-B2 | Antiparisitic and pesticidal isoxazoline compounds | MERIAL, INC. (US) | 2016-09-20 | — | — | US | disclosed |
| US-9447084-B2 | Antiparisitic and pesticidal isoxazoline compounds | MERIAL, INC. (US) | 2016-09-20 | — | — | US | disclosed |
| EP-3063144-A1 | ANTIPARISITIC AND PESTICIDAL ISOXAZOLINE COMPOUNDS | Merial, Inc. (US) | 2016-09-07 | — | — | EP | disclosed |
| US-20150126523-A1 | ANTIPARISITIC AND PESTICIDAL ISOXAZOLINE COMPOUNDS | MERIAL LIMITED (US) | 2015-05-07 | — | — | US | disclosed |
| WO-2015066277-A1 | ANTIPARISITIC AND PESTICIDAL ISOXAZOLINE COMPOUNDS | MERIAL LIMITED (US) | 2015-05-07 | — | — | WO | disclosed |
| WO-2015066277-A1 | ANTIPARISITIC AND PESTICIDAL ISOXAZOLINE COMPOUNDS | MERIAL LIMITED (US) | 2015-05-07 | — | — | WO | disclosed |
| EP-2002837-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-12-17 | — | — | EP | disclosed |
| EP-1094816-B1 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2008-12-10 | — | — | EP | disclosed |
| EP-1741713-A2 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | Bristol-Myers Squibb Company (US) | 2007-01-10 | — | — | EP | disclosed |
| EP-1237888-B1 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2006-09-13 | — | — | EP | disclosed |
| US-6852745-B2 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-02-08 | — | — | US | disclosed |
| US-6835741-B2 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | BRISTOL-MYERS SQUIBB COMPANY | 2004-12-28 | — | — | US | disclosed |
| US-20040127515-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | PHARMACOPEIA, LLC | 2004-07-01 | — | — | US | disclosed |
| US-20040106833-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | PHARMACOPEIA, LLC | 2004-06-03 | — | — | US | disclosed |
| US-6638937-B2 | As antihypertensive agents; for therapy of disorders related to renal, glomerular and mesangial cell function; therapy of endotoxemia or endotoxin shock as well as hemorrhagic shock; useful in alleviation of pain associated cancer | BRISTOL-MYERS SQUIBB CO. | 2003-10-28 | — | — | US | disclosed |
| US-20020143024-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | PHARMACOPEIA, LLC | 2002-10-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127515-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | EDNRB, AGTR2, EDNRA | NOTUM 2409/4885PDK2 3673/4885CCR6 3435/4885 |
| US-20020143024-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | EDNRB, AGTR2, EDNRA | NOTUM 2409/4885PDK2 3673/4885CCR6 3435/4885 |
| US-20040106833-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | EDNRB, AGTR2, EDNRA | NOTUM 2409/4885PDK2 3673/4885CCR6 3435/4885 |
| US-20150126523-A1 | ANTIPARISITIC AND PESTICIDAL ISOXAZOLINE COMPOUNDS | ACHE, PRDX1, CHRM1 | NOTUM 1693/4885PDK2 674/4885CCR6 3797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.