Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9197494 | 0.80 | SLC6A2 (0.36) | SLC6A3SLC6A2SLC6A4ALDH1A1TSHR | |
| SCHEMBL5592440 | 0.80 | ALDH1A1 (0.40) | ALDH1A1TSHR | |
| SCHEMBL14942027 | 0.80 | SLC6A3 (0.45) | SLC6A3SLC6A2SLC6A4DHFRALDH1A1 | |
| SCHEMBL856505 | 0.79 | SLC6A3 (0.39) | SLC6A3SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL9341311 | 0.78 | SLC6A3 (0.52) | SLC6A3SLC6A2SLC6A4DHFR | |
| SCHEMBL6207732 | 0.77 | PRCP (0.41) | SLC6A3SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL3982507 | 0.77 | PRCP (0.41) | SLC6A3SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL8569265 | 0.77 | PRCP (0.41) | SLC6A3SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL30166189 | 0.75 | SLC6A3 (0.40) | SLC6A3SLC6A2SLC6A4DHFRALDH1A1 | |
| SCHEMBL4553209 | 0.74 | SLC6A3 (0.47) | SLC6A3SLC6A2SLC6A4DHFRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572678-A4 | SUBSTITUTED N-PHENYL SULFONAMIDE BRADYKININ ANTAGONISTS | ELAN PHARM INC (US) | 2008-05-07 | — | — | EP | disclosed |
| EP-1572678-A2 | SUBSTITUTED N-PHENYL SULFONAMIDE BRADYKININ ANTAGONISTS | Elan Pharmaceuticals, Inc. (US) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004056319-A2 | SUBSTITUTED N-PHENYL SULFONAMIDE BRADYKININ ANTAGONISTS | ELAN PHARMACEUTICALS INC. (US) | 2004-07-08 | — | — | WO | disclosed |