Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | TLR2 | O60603 | 2/20 | 0.38 |
| ▸ | PRCP | P42785 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8569265 | 0.84 | PRCP (0.41) | SLC6A3SLC6A2SLC6A4TLR2PRCP | |
| SCHEMBL6207732 | 0.84 | PRCP (0.41) | SLC6A3SLC6A2SLC6A4TLR2PRCP | |
| SCHEMBL3982507 | 0.84 | PRCP (0.41) | SLC6A3SLC6A2SLC6A4TLR2PRCP | |
| SCHEMBL30166189 | 0.81 | SLC6A3 (0.40) | SLC6A3SLC6A2SLC6A4TLR2PRCP | |
| SCHEMBL4774438 | 0.79 | SLC6A3 (0.41) | SLC6A3SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL9197494 | 0.78 | SLC6A2 (0.36) | SLC6A3SLC6A2SLC6A4TLR2PRCP | |
| SCHEMBL14942027 | 0.77 | SLC6A3 (0.45) | SLC6A3SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL16145881 | 0.76 | ALDH1A1 (0.42) | ALDH1A1 | |
| SCHEMBL16145640 | 0.76 | ALDH1A1 (0.45) | ALDH1A1 | |
| SCHEMBL13387496 | 0.75 | TSHR (0.43) | SLC6A3SLC6A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432760-A1 | BRIDGED SPIRO [2.4]HEPTANE DERIVATIVES AS ALX RECEPTOR AND/OR FPRL2 AGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010134014-A1 | BRIDGED SPIRO [2.4] HEPTANE DERIVATIVES AS ALX RECEPTOR AND/OR FPRL2 AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2010-11-25 | — | — | WO | disclosed |