Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 8/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4140218 | 0.80 | KDM4E (0.41) | ALDH1A1TSHRKDM4EKMT2A | |
| SCHEMBL4149074 | 0.80 | KDM4E (0.41) | ALDH1A1TSHRKDM4EKMT2A | |
| SCHEMBL13872475 | 0.80 | MAOA (0.54) | ALDH1A1KDM4EKMT2A | |
| SCHEMBL13872442 | 0.80 | MAOA (0.54) | ALDH1A1KDM4EKMT2A | |
| SCHEMBL15148123 | 0.76 | LMNA (0.49) | LMNAALDH1A1TSHRMAPK1HTT | |
| SCHEMBL22729315 | 0.75 | KDM4E (0.42) | ALDH1A1TSHRKDM4EKMT2A | |
| SCHEMBL13323158 | 0.75 | ALDH1A1 (0.56) | LMNAALDH1A1TSHRHTTACHE | |
| SCHEMBL10141268 | 0.75 | ACHE (0.58) | LMNAALDH1A1ACHESMN1; SMN2ALOX15 | |
| SCHEMBL10119353 | 0.75 | LMNA (0.51) | LMNAALDH1A1TSHRMAPK1HTT | |
| SCHEMBL8193146 | 0.75 | ACHE (0.53) | LMNAALDH1A1TSHRMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940785-A2 | ACYCLIC 1,4-DIAMINES AND USES THEREOF | SmithKline Beecham Corporation (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007030761-A2 | ACYCLIC 1,4-DIAMINES AND USES THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-15 | — | — | WO | disclosed |