Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | PPARA | Q07869 | 3/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | PPARD | Q03181 | 1/20 | 0.51 |
| ▸ | FDPS | P14324 | 1/20 | 0.49 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5050752 | 0.93 | MEN1 (0.52) | MEN1NPC1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL16973543 | 0.92 | PPARA (0.50) | MEN1NPC1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL881495 | 0.85 | MEN1 (0.45) | MEN1NPC1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL30644304 | 0.84 | ALDH1A1 (0.69) | MEN1KMT2AL3MBTL1ALDH1A1PPARA | |
| SCHEMBL557409 | 0.84 | ALDH1A1 (0.69) | MEN1KMT2AL3MBTL1ALDH1A1PPARA | |
| SCHEMBL3343652 | 0.83 | ALDH1A1 (0.67) | MEN1KMT2AL3MBTL1ALDH1A1PPARA | |
| SCHEMBL1766003 | 0.79 | PPARA (0.54) | MEN1NPC1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL8788295 | 0.79 | FDPS (0.51) | MEN1NPC1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL18244599 | 0.79 | ALDH1A1 (0.63) | MEN1NPC1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL5978889 | 0.79 | ALDH1A1 (0.53) | MEN1NPC1KMT2AL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1991531-A1 | CINNOLINE AND QUINOXALINE DERIVATES AS PHOSPHODIESTERASE 10 INHIBITORS | Amgen Inc. (US) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007100880-A1 | CINNOLINE AND QUINAZOLINE DERIVATES AS PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2007-09-07 | — | — | WO | disclosed |