Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.42 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL739535 | 1.00 | SIGMAR1 (0.47) | SIGMAR1DRD2NPFFR1NPFFR2OPRM1 | |
| SCHEMBL81713 | 0.89 | NPFFR1 (0.50) | SIGMAR1NPFFR1NPFFR2CA12CA1 | |
| SCHEMBL4772739 | 0.78 | SIGMAR1 (0.41) | SIGMAR1DRD2NPFFR1NPFFR2OPRM1 | |
| SCHEMBL4772742 | 0.78 | SIGMAR1 (0.41) | SIGMAR1DRD2NPFFR1NPFFR2OPRM1 | |
| SCHEMBL27929854 | 0.77 | NPFFR1 (0.48) | SIGMAR1DRD2NPFFR1NPFFR2OPRM1 | |
| SCHEMBL27947092 | 0.77 | NPFFR1 (0.48) | SIGMAR1DRD2NPFFR1NPFFR2OPRM1 | |
| SCHEMBL5067807 | 0.75 | DRD2 (0.45) | SIGMAR1DRD2NPFFR1NPFFR2OPRM1 | |
| SCHEMBL8541686 | 0.75 | SIGMAR1 (0.44) | SIGMAR1DRD2NPFFR1NPFFR2CA12 | |
| SCHEMBL6008955 | 0.75 | SIGMAR1 (0.44) | SIGMAR1DRD2NPFFR1NPFFR2CA12 | |
| SCHEMBL739534 | 0.74 | OPRL1 (0.37) | OPRM1CTSSCTSKOPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1930321-A1 | PROCESS FOR PREPARATION OF TETRASUBSTITUTED 5-AZASPIRO[2.4]- HEPTANE DERIVATIVES AND OPTICALLY ACTIVE INTERMEDIATES THEREOF | Daiichi Sankyo Company, Limited (JP) | 2008-06-11 | — | — | EP | claimed |