Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 5/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.38 |
| ▸ | CSF1R | P07333 | 5/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4768934 | 0.94 | CSF1R (0.45) | SLC6A2SLC6A4CSF1RSLC6A3KCNH2 | |
| SCHEMBL4775791 | 0.92 | CSF1R (0.39) | SLC6A2SLC6A4CSF1RSLC6A3KDM4E | |
| SCHEMBL4777730 | 0.81 | CSF1R (0.57) | CSF1R | |
| SCHEMBL4775794 | 0.80 | CSF1R (0.55) | CSF1R | |
| SCHEMBL11016385 | 0.76 | CSF1R (0.46) | CSF1RKDM4EMAPK1LMNACASP1 | |
| SCHEMBL4775340 | 0.73 | CSF1R (0.48) | CSF1RKCNH2PDE4ACHEK1 | |
| SCHEMBL4773616 | 0.73 | CSF1R (0.43) | CSF1RKDM4EMAPK1LMNAMEN1 | |
| SCHEMBL4768393 | 0.73 | CSF1R (0.47) | CSF1RPDE4A | |
| SCHEMBL4769014 | 0.73 | CSF1R (0.42) | CSF1RKDM4EMAPK1ALDH1A1KCNH2 | |
| SCHEMBL4771887 | 0.72 | CSF1R (0.40) | CSF1RKDM4EMAPK1KCNH2PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945637-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007033137-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-03-22 | — | — | WO | disclosed |