Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.49 |
| ▸ | DRD3 | P35462 | 4/20 | 0.49 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.47 |
| ▸ | MCOLN1 | Q9GZU1 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29138516 | 0.81 | DRD2 (0.49) | DRD2DRD3DRD4ALDH1A1HSD11B1 | |
| SCHEMBL17376246 | 0.80 | MCOLN2 (0.50) | DRD2DRD3MCOLN2MCOLN1DRD4 | |
| SCHEMBL29138525 | 0.79 | DRD2 (0.53) | DRD2DRD3DRD4ALDH1A1KMT2A | |
| SCHEMBL20140998 | 0.79 | MCOLN2 (0.55) | DRD2DRD3MCOLN2MCOLN1DRD4 | |
| SCHEMBL4896088 | 0.75 | NOTUM (0.46) | ALDH1A1KMT2AMEN1LMNATSHR | |
| SCHEMBL29138547 | 0.75 | DRD2 (0.56) | DRD2DRD3ALDH1A1KMT2AMEN1 | |
| SCHEMBL34463006 | 0.73 | DRD2 (0.58) | DRD2DRD3DRD4ALDH1A1KMT2A | |
| SCHEMBL34462822 | 0.72 | DRD2 (0.56) | DRD2DRD3ALDH1A1HSD11B1LMNA | |
| SCHEMBL3904994 | 0.70 | KMT2A (0.68) | DRD2DRD3ALDH1A1KMT2APKM | |
| SCHEMBL4778958 | 0.69 | ADRA1D (0.48) | DRD2DRD3DRD4ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008010061-A2 | 3-AZABICYCLO [3.1.0] HEXANE VANILLOID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION | GLENMARK PHARMACEUTICALS S.A. (US) | 2008-01-24 | — | — | WO | disclosed |