Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.39 |
| ▸ | S1PR2 | O95136 | 4/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781138 | 0.83 | S1PR1 (0.39) | S1PR1S1PR3S1PR2S1PR4CNR1 | |
| SCHEMBL4795346 | 0.81 | CTSK (0.41) | CTSKNPSR1SIGMAR1BCHEP2RY14 | |
| SCHEMBL4780934 | 0.76 | DHODH (0.40) | MAPTPTGESALOX5 | |
| SCHEMBL4776475 | 0.76 | TNKS2 (0.39) | CNR1MEN1KMT2ASIGMAR1ACHE | |
| SCHEMBL16492758 | 0.76 | S1PR1 (0.51) | CTSKS1PR1S1PR3S1PR2S1PR4 | |
| SCHEMBL6559442 | 0.73 | ATM (0.55) | CTSKNPSR1MEN1KMT2ASIGMAR1 | |
| SCHEMBL16151782 | 0.72 | MAOA (0.56) | NPSR1SIGMAR1BCHEACHE | |
| SCHEMBL13426175 | 0.71 | ATM (0.55) | NPSR1MEN1KMT2ASIGMAR1BCHE | |
| SCHEMBL16151781 | 0.69 | CYP3A4 (0.46) | CTSK | |
| SCHEMBL4774621 | 0.69 | DHODH (0.41) | MAPTPTGESALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009963-A2 | PYRIMIDINE DERIVATIVES AS MODULATORS OF PARATHYROID HORMONE RECEPTORS | JAMES BLACK FOUNDATION LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |