Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PREP | P48147 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28970107 | 0.88 | PREP (0.36) | L3MBTL1MEN1KMT2AALDH1A1PREP | |
| SCHEMBL5697477 | 0.80 | NR1H2 (0.39) | NFKB1NFKB2RELAL3MBTL1ALDH1A1 | |
| SCHEMBL28679752 | 0.72 | ADORA1 (0.40) | GLANFKB1NFKB2RELACRHBP | |
| SCHEMBL17267602 | 0.70 | ESR2 (0.38) | NFKB1NFKB2RELAMEN1KMT2A | |
| SCHEMBL30910213 | 0.69 | ACHE (0.40) | MEN1KMT2AALDH1A1 | |
| SCHEMBL28670678 | 0.68 | GLA (0.39) | GLANFKB1NFKB2RELACRHBP | |
| SCHEMBL4777252 | 0.67 | GLA (0.36) | GLANFKB1NFKB2RELACRHBP | |
| SCHEMBL13947269 | 0.65 | TP53 (0.36) | NFKB1NFKB2RELAMEN1KMT2A | |
| SCHEMBL20670426 | 0.65 | GLA (0.42) | GLANFKB1NFKB2RELAADORA1 | |
| SCHEMBL4410627 | 0.64 | GLA (0.39) | GLANFKB1NFKB2RELAADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968976-A1 | SUBSTITUTED PYRAZOLO [4,3-C] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007068619-A1 | SUBSTITUTED PYRAZOLO [4,3-C] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2007-06-21 | — | — | WO | disclosed |