Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | EED | O75530 | 1/20 | 0.33 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.33 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.33 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.33 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PREP | P48147 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28970107 | 0.91 | PREP (0.36) | NR1H2ALDH1A1MAPTHTTNPC1 | |
| SCHEMBL4777248 | 0.80 | GLA (0.36) | ALDH1A1L3MBTL1PREPNFKB1NFKB2 | |
| SCHEMBL17267602 | 0.78 | ESR2 (0.38) | NR1H2ALDH1A1USP30MAPTPREP | |
| SCHEMBL3110330 | 0.71 | MAPT (0.36) | NR1H2ALDH1A1MAPTPREPESR2 | |
| SCHEMBL7484898 | 0.69 | GPR119 (0.34) | ALDH1A1MAPTNPC1MAPK1RAB9A | |
| SCHEMBL19282499 | 0.67 | SMN1; SMN2 (0.32) | SMN1; SMN2 | |
| SCHEMBL1838102 | 0.66 | PREP (0.37) | NR1H2ALDH1A1MAPTPREPESR2 | |
| SCHEMBL15414407 | 0.66 | PREP (0.40) | NR1H2ALDH1A1MAPTPREPESR2 | |
| SCHEMBL28696148 | 0.66 | NR1H2 (0.38) | NR1H2HDAC1HDAC6EEDRBBP4 | |
| SCHEMBL28679752 | 0.66 | ADORA1 (0.40) | ALDH1A1L3MBTL1LMNASMN1; SMN2NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673341-A1 | TETRAHYDROPYRIDINE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005040120-A1 | TETRAHYDROPYRIDINE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2005-05-06 | — | — | WO | disclosed |