Sugi Predict

Sugi Predict / Compounds / SCHEMBL4777342

SCHEMBL4777342

SCHEMBL4777342

CS(=O)(=O)N(Cc1cccc(Cl)c1Cl)c1ccc(C(C(N)=O)C2(O)CCCCC2)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.38
▸ GAA P10253 2/20 0.36
▸ CHRM2 P08172 2/20 0.34
▸ CHRM1 P11229 2/20 0.34
▸ CHRM3 P20309 2/20 0.34
▸ CHRM4 P08173 1/20 0.34
▸ LMNA P02545 5/20 0.34
▸ MAPT P10636 3/20 0.34
▸ CYP3A4 P08684 2/20 0.34
▸ CYP2D6 P10635 2/20 0.34
▸ CYP1A2 P05177 1/20 0.34
▸ GLA P06280 1/20 0.34
▸ CYP2C9 P11712 1/20 0.34
▸ CYP2C19 P33261 1/20 0.34
▸ NPSR1 Q6W5P4 1/20 0.34
▸ SLC6A2 P23975 3/20 0.33
▸ SLC6A4 P31645 3/20 0.33
▸ SLC6A3 Q01959 2/20 0.33
▸ SMN1; SMN2 Q16637 2/20 0.33
▸ KCNH2 Q12809 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5571822 0.79 ALDH1A1 (0.42) ALDH1A1GAALMNAMAPTCYP3A4
SCHEMBL4775086 0.77 P2RX7 (0.41) ALDH1A1GAALMNACYP1A2CYP2C9
SCHEMBL4775063 0.77 GAA (0.40) ALDH1A1GAALMNAMAPTCYP3A4
SCHEMBL4769594 0.76 GAA (0.48) ALDH1A1GAALMNAMAPTNPSR1
SCHEMBL4771366 0.75 GAA (0.39) ALDH1A1GAALMNAMAPTCYP3A4
SCHEMBL4776560 0.75 RECQL (0.44) ALDH1A1GAAMAPTCYP3A4CYP2D6
SCHEMBL4777338 0.75 ALDH1A1 (0.37) ALDH1A1GAALMNAMAPTNPSR1
SCHEMBL4771209 0.75 GAA (0.39) ALDH1A1GAALMNAMAPTTP53
SCHEMBL4773509 0.75 GAA (0.41) ALDH1A1GAALMNAMAPTCYP3A4
SCHEMBL4777308 0.75 SLC6A4 (0.45) ALDH1A1GAACYP3A4CYP2D6SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1942888-A2 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS Cytokinetics, Inc. (US) 2008-07-16 — — EP claimed
US-20070135435-A1 Certain chemical entities, compositions, and methods CYTOKINETICS, INCORPORATED 2007-06-14 — — US claimed
WO-2007056078-A2 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS CYTOKINETICS, INC. (US) 2007-05-18 — — WO claimed
EP-1942888-A2 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS Cytokinetics, Inc. (US) 2008-07-16 — — EP disclosed
US-20070135435-A1 Certain chemical entities, compositions, and methods CYTOKINETICS, INCORPORATED 2007-06-14 — — US disclosed
WO-2007056078-A2 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS CYTOKINETICS, INC. (US) 2007-05-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070135435-A1 Certain chemical entities, compositions, and methods KIF5B, KIF2C, PLK1 ALDH1A1 2159/4885GAA 466/4885CHRM2 3656/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.