Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.41 |
| ▸ | PTPN5 | P54829 | 3/20 | 0.41 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.41 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4726823 | 0.84 | MEN1 (0.55) | LMNANPSR1SLC40A1MEN1KMT2A | |
| SCHEMBL31478890 | 0.84 | MEN1 (0.55) | LMNANPSR1SLC40A1MEN1KMT2A | |
| SCHEMBL30304724 | 0.84 | AXL (0.47) | LMNANPSR1SLC40A1MEN1KMT2A | |
| SCHEMBL4780564 | 0.84 | AXL (0.47) | LMNANPSR1SLC40A1MEN1KMT2A | |
| SCHEMBL4846633 | 0.83 | SLC20A2 (0.49) | LMNANPSR1SLC40A1MEN1KMT2A | |
| SCHEMBL4775594 | 0.81 | SLC20A2 (0.51) | LMNANPSR1SLC40A1MEN1KMT2A | |
| SCHEMBL4781821 | 0.81 | SLC40A1 (0.49) | LMNANPSR1SLC40A1MEN1KMT2A | |
| SCHEMBL6378305 | 0.79 | GAA (0.43) | LMNANPSR1SLC40A1MEN1KMT2A | |
| SCHEMBL4725832 | 0.77 | LMNA (0.47) | LMNANPSR1SLC40A1MEN1KMT2A | |
| SCHEMBL8658028 | 0.76 | PTGES2 (0.51) | LMNANPSR1MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008442-A1 | PREPARATION AND UTILITY OF HMG-COA REDUCTASE INHIBITORS | AUSPEX PHARMACEUTICALS, INC. (US) | 2008-01-17 | — | — | WO | disclosed |
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |