Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.49 |
| ▸ | RELA | Q04206 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | APP | P05067 | 10/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781491 | 0.86 | NPC1 (0.50) | ALDH1A1SMN1; SMN2NPC1RAB9ANFKB1 | |
| SCHEMBL4725302 | 0.79 | APP (0.64) | ALDH1A1SMN1; SMN2NPC1RAB9ANFKB1 | |
| SCHEMBL4726842 | 0.79 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2NPC1RAB9ANFKB1 | |
| SCHEMBL2128024 | 0.72 | RAB9A (0.66) | ALDH1A1SMN1; SMN2NPC1RAB9ANFKB1 | |
| SCHEMBL4781097 | 0.72 | APP (0.64) | ALDH1A1SMN1; SMN2NPC1RAB9ANFKB1 | |
| SCHEMBL4727600 | 0.71 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2NPC1RAB9ANFKB1 | |
| SCHEMBL4842127 | 0.71 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2NPC1RAB9ANFKB1 | |
| SCHEMBL4727599 | 0.71 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2NPC1RAB9ANFKB1 | |
| SCHEMBL2127619 | 0.70 | RAB9A (0.55) | ALDH1A1SMN1; SMN2NPC1RAB9ANFKB1 | |
| SCHEMBL4726932 | 0.68 | RAB9A (0.64) | ALDH1A1SMN1; SMN2NPC1RAB9ANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008029152-A2 | TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2008-03-13 | — | — | WO | disclosed |