Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 11/20 | 0.64 |
| ▸ | RAB9A | P51151 | 7/20 | 0.59 |
| ▸ | NPC1 | O15118 | 7/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.59 |
| ▸ | RELA | Q04206 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4725742 | 0.85 | APP (0.72) | APPRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4729886 | 0.82 | APP (0.64) | APPRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4729831 | 0.80 | APP (0.72) | APPRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4842127 | 0.76 | ALDH1A1 (0.57) | RAB9ANPC1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL4726932 | 0.76 | RAB9A (0.64) | APPRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL12692455 | 0.75 | RAB9A (0.97) | APPRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4727745 | 0.75 | RAB9A (0.68) | APPRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4725302 | 0.75 | APP (0.64) | APPRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4778210 | 0.72 | ALDH1A1 (0.49) | APPRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4727600 | 0.72 | ALDH1A1 (0.52) | RAB9ANPC1ALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008029152-A2 | TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2008-03-13 | — | — | WO | disclosed |