Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 9/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4580699 | 0.74 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1CYP11B2 | |
| SCHEMBL8553015 | 0.66 | SMN1; SMN2 (0.47) | TSHRHSD17B10HDAC6HPGDSMN1; SMN2 | |
| SCHEMBL4581914 | 0.62 | CYP11B2 (0.42) | CYP11B2HPGD | |
| SCHEMBL15088518 | 0.59 | NAMPT (0.54) | HDAC4HDAC6HPGDSMN1; SMN2 | |
| SCHEMBL14222294 | 0.58 | IDO1 (0.38) | GABRA5HSD17B10CYP11B2GABRA1HPGD | |
| SCHEMBL31375578 | 0.58 | ALDH1A1 (0.64) | HDAC6LMNAHPGDSMN1; SMN2 | |
| SCHEMBL8387722 | 0.57 | DEGS1 (0.53) | L3MBTL1HPGDSMN1; SMN2 | |
| SCHEMBL10557090 | 0.57 | CARM1 (0.52) | HDAC4HDAC6 | |
| SCHEMBL5497348 | 0.56 | RAB9A (0.56) | HDAC4HDAC6HPGDSMN1; SMN2 | |
| SCHEMBL29268969 | 0.56 | NPC1 (0.55) | HSD17B10HDAC6HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008024978-A2 | TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES | SERENEX, INC. (US) | 2008-02-28 | — | — | WO | disclosed |