Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | GAA | P10253 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NCF1 | P14598 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 4/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5128181 | 0.80 | MAP4K4 (0.43) | ALDH1A1GAAKDM4ESMN1; SMN2NCF1 | |
| SCHEMBL31052606 | 0.79 | MAPT (0.53) | MEN1KMT2ACYP1A2MAPTCYP2D6 | |
| SCHEMBL3837306 | 0.78 | LMNA (0.53) | GAAKDM4EHSD17B10TSHRCASP1 | |
| Hydrochloric Acid SCHEMBL31052704 | 0.77 | MAPT (0.51) | CYP1A2MAPTCYP2D6GAAKDM4E | |
| SCHEMBL4659260 | 0.77 | NPC1 (0.45) | NPC1RAB9AMEN1KMT2ACYP1A2 | |
| SCHEMBL4918026 | 0.76 | P2RX7 (0.55) | SMPD3 | |
| SCHEMBL21154003 | 0.75 | KMT2A (0.51) | NPC1RAB9AMEN1KMT2ACYP1A2 | |
| SCHEMBL4921435 | 0.74 | P2RX7 (0.53) | NPC1RAB9AMEN1KMT2ACYP1A2 | |
| SCHEMBL12701772 | 0.72 | ALDH1A1 (0.56) | NPC1RAB9AMEN1KMT2ACYP1A2 | |
| SCHEMBL2369964 | 0.72 | CNR2 (0.50) | MEN1KMT2ACYP1A2MAPTCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080058309-A1 | Novel Compounds 171 | ASTRAZENECA AB | 2008-03-06 | — | — | US | disclosed |
| WO-2008013494-A1 | QUINOLINE DERIVATIVES AS P2X7 RECEPTOR ANTAGONIST AND THEIR USE IN THE TREATMENT OF RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, COPD AND IBD | ASTRAZENECA AB (SE) | 2008-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058309-A1 | Novel Compounds 171 | C1R, F12, ADRA1D | NPC1 371/4885RAB9A 543/4885MEN1 773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.