Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.41 |
| ▸ | KLK1 | P06870 | 1/20 | 0.39 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.39 |
| ▸ | PTH1R | Q03431 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 9/20 | 0.37 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4778364 | 0.91 | TERT (0.58) | TERTTAAR1TBXAS1KLK1KLK5 | |
| SCHEMBL4774136 | 0.82 | TERT (0.47) | TERTTAAR1TBXAS1KLK1KLK5 | |
| SCHEMBL6572107 | 0.82 | TERT (0.47) | TERTTAAR1TBXAS1KLK1KLK5 | |
| SCHEMBL4776175 | 0.81 | TAAR1 (0.70) | TERTTAAR1KLK1KLK5PTH1R | |
| SCHEMBL5526585 | 0.79 | TERT (0.47) | TERTTAAR1TBXAS1KLK1KLK5 | |
| SCHEMBL5362554 | 0.78 | TBXAS1 (0.45) | TERTTAAR1TBXAS1NAMPT | |
| SCHEMBL7497236 | 0.76 | ALDH1A1 (0.41) | TERTTBXAS1 | |
| SCHEMBL5191160 | 0.76 | ALDH1A1 (0.48) | TERTTAAR1 | |
| SCHEMBL27220846 | 0.75 | TERT (0.56) | TERTTAAR1TBXAS1NAMPTPBK | |
| SCHEMBL9666999 | 0.74 | TAAR1 (0.70) | TERTTAAR1TBXAS1KLK1KLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009963-A2 | PYRIMIDINE DERIVATIVES AS MODULATORS OF PARATHYROID HORMONE RECEPTORS | JAMES BLACK FOUNDATION LIMITED (GB) | 2008-01-24 | — | — | WO | claimed |
| WO-2008009963-A2 | PYRIMIDINE DERIVATIVES AS MODULATORS OF PARATHYROID HORMONE RECEPTORS | JAMES BLACK FOUNDATION LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |
| WO-2006129120-A9 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2007-03-22 | — | — | WO | disclosed |
| WO-2006129120-A2 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2006-12-07 | — | — | WO | disclosed |