Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.59 |
| ▸ | UBE2M | P61081 | 4/20 | 0.49 |
| ▸ | DCUN1D1 | Q96GG9 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | AKT1 | P31749 | 3/20 | 0.42 |
| ▸ | AKT2 | P31751 | 3/20 | 0.42 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 8/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7425451 | 0.78 | DRD2 (0.47) | MAPTAKT1AKT2AKT3ALDH1A1 | |
| SCHEMBL4778446 | 0.78 | HDAC8 (0.60) | HDAC8MAPTAKT1AKT2AKT3 | |
| Bromide SCHEMBL7418489 | 0.77 | DRD2 (0.46) | MAPTAKT1AKT2AKT3ALDH1A1 | |
| Bromide SCHEMBL7418493 | 0.77 | DRD2 (0.46) | MAPTAKT1AKT2AKT3ALDH1A1 | |
| Bromide SCHEMBL7425690 | 0.77 | DRD2 (0.46) | MAPTAKT1AKT2AKT3ALDH1A1 | |
| Bromide SCHEMBL7425687 | 0.77 | DRD2 (0.46) | MAPTAKT1AKT2AKT3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7422561 | 0.77 | NPC1 (0.52) | MAPTALDH1A1GAA | |
| SCHEMBL4792379 | 0.77 | HDAC8 (0.66) | HDAC8AKT1ALDH1A1GAAPARP1 | |
| SCHEMBL4778346 | 0.77 | SMN1; SMN2 (0.48) | MAPTALDH1A1 | |
| SCHEMBL7418322 | 0.77 | MAPT (0.44) | MAPTALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996550-A2 | CARBOXYAMINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF HDAC DEPENDENT DISEASES | Novartis AG (CH) | 2008-12-03 | — | — | EP | claimed |
| US-20080255149-A1 | Carboxyamine Compounds and Methods of Use Thereof | NOVARTIS AG | 2008-10-16 | — | — | US | claimed |
| WO-2007038459-A2 | CARBOXYAMINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF HDAC DEPENDENT DISEASES | NOVARTIS AG (CH) | 2007-04-05 | — | — | WO | claimed |
| EP-1996550-A2 | CARBOXYAMINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF HDAC DEPENDENT DISEASES | Novartis AG (CH) | 2008-12-03 | — | — | EP | disclosed |
| US-20080255149-A1 | Carboxyamine Compounds and Methods of Use Thereof | NOVARTIS AG | 2008-10-16 | — | — | US | disclosed |
| WO-2007038459-A2 | CARBOXYAMINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF HDAC DEPENDENT DISEASES | NOVARTIS AG (CH) | 2007-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255149-A1 | Carboxyamine Compounds and Methods of Use Thereof | HNMT, HDAC5, HDAC4 | HDAC8 16/4885UBE2M 2925/4885DCUN1D1 2226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.