Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4777631 | 1.00 | ALDH1A1 (0.55) | ALDH1A1MAPTKMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL4021931 | 1.00 | ALDH1A1 (0.55) | ALDH1A1MAPTKMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL4020945 | 0.84 | ALDH1A1 (0.51) | ALDH1A1MAPTKMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL4026119 | 0.83 | SLC18A3 (0.45) | ALDH1A1KMT2ALMNACYP2C19MEN1 | |
| SCHEMBL4024282 | 0.83 | SLC18A3 (0.45) | ALDH1A1KMT2ALMNACYP2C19MEN1 | |
| SCHEMBL4772340 | 0.82 | KMT2A (0.48) | ALDH1A1KMT2ALMNAMEN1 | |
| SCHEMBL4026548 | 0.82 | KMT2A (0.46) | ALDH1A1MAPTKMT2AKDM4ELMNA | |
| SCHEMBL4019381 | 0.82 | KMT2A (0.46) | ALDH1A1MAPTKMT2AKDM4ELMNA | |
| SCHEMBL4019373 | 0.82 | KMT2A (0.46) | ALDH1A1MAPTKMT2AKDM4ELMNA | |
| SCHEMBL4776822 | 0.81 | ALDH1A1 (0.46) | ALDH1A1MAPTKMT2AKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | disclosed |