Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.37 |
| ▸ | UBE2M | P61081 | 1/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | C5AR1 | P21730 | 2/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | RBP4 | P02753 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781028 | 0.90 | KDM4E (0.43) | NOTUMKDM4EALDH1A1ATMHSD11B1 | |
| SCHEMBL4780332 | 0.87 | CHRM4 (0.38) | NOTUMKDM4EALDH1A1UBE2MDCUN1D1 | |
| SCHEMBL4778369 | 0.80 | NOTUM (0.40) | NOTUMKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL4774338 | 0.80 | DRD2 (0.32) | KDM4EALDH1A1CHRM4DRD2DRD3 | |
| SCHEMBL4779536 | 0.80 | DRD2 (0.32) | KDM4EALDH1A1CHRM4DRD2DRD3 | |
| SCHEMBL4776176 | 0.77 | FFAR4 (0.40) | UBE2MDCUN1D1KMT2AMEN1 | |
| SCHEMBL4776370 | 0.77 | CHRM4 (0.42) | UBE2MDCUN1D1CHRM4DRD2DRD3 | |
| SCHEMBL4780326 | 0.76 | CHRM4 (0.40) | KDM4EALDH1A1UBE2MDCUN1D1CHRM4 | |
| SCHEMBL4774390 | 0.75 | KDM4E (0.40) | KDM4EALDH1A1ATMKMT2AMEN1 | |
| SCHEMBL4780839 | 0.74 | SLC6A2 (0.44) | NOTUMCHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008010061-A2 | 3-AZABICYCLO [3.1.0] HEXANE VANILLOID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION | GLENMARK PHARMACEUTICALS S.A. (US) | 2008-01-24 | — | — | WO | disclosed |