Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | UBE2M | P61081 | 1/20 | 0.33 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4778369 | 0.90 | NOTUM (0.40) | CHRM4KDM4EALDH1A1SMN1; SMN2DRD2 | |
| SCHEMBL4774338 | 0.89 | DRD2 (0.32) | CHRM4KDM4EALDH1A1SMN1; SMN2DRD2 | |
| SCHEMBL4779536 | 0.89 | DRD2 (0.32) | CHRM4KDM4EALDH1A1SMN1; SMN2DRD2 | |
| SCHEMBL4779453 | 0.87 | NOTUM (0.46) | CHRM4KDM4EALDH1A1DRD2DRD3 | |
| SCHEMBL4774390 | 0.85 | KDM4E (0.40) | KDM4EALDH1A1SMN1; SMN2DRD2DRD3 | |
| SCHEMBL4780326 | 0.82 | CHRM4 (0.40) | CHRM4KDM4EALDH1A1SMN1; SMN2DRD2 | |
| SCHEMBL4321609 | 0.80 | GRM5 (0.42) | CHRM4ALDH1A1DRD2DRD3KMT2A | |
| SCHEMBL4779333 | 0.80 | CHRM4 (0.39) | CHRM4UBE2MDCUN1D1 | |
| SCHEMBL4781028 | 0.78 | KDM4E (0.43) | KDM4EALDH1A1KMT2ANOTUMCYP2C9 | |
| SCHEMBL4779787 | 0.78 | FFAR4 (0.38) | UBE2MDCUN1D1KMT2APOLBCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008010061-A2 | 3-AZABICYCLO [3.1.0] HEXANE VANILLOID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION | GLENMARK PHARMACEUTICALS S.A. (US) | 2008-01-24 | — | — | WO | disclosed |