SCHEMBL4725344

SCHEMBL4725344

OC(c1ccccc1)(c1ccccc1)c1cc(CBr)no1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 1/20 0.36
KMT2A Q03164 4/20 0.33
MEN1 O00255 3/20 0.33
CHRM2 P08172 2/20 0.33
CHRM4 P08173 2/20 0.33
CHRM5 P08912 2/20 0.33
CHRM1 P11229 2/20 0.33
CHRM3 P20309 2/20 0.33
RAB9A P51151 2/20 0.33
NPC1 O15118 1/20 0.33
CYP19A1 P11511 5/20 0.33
ALDH1A1 P00352 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
CFTR P13569 1/20 0.31
GOPC Q9HD26 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4779771 0.85 NOTUM (0.51) NOTUMKMT2AMEN1CHRM2CHRM4
SCHEMBL4725676 0.81 HRH1 (0.35) NOTUMKMT2AMEN1CHRM2CHRM4
SCHEMBL4777782 0.80 MEN1 (0.35) NOTUMKMT2AMEN1CHRM2CHRM4
SCHEMBL14291874 0.80 CYP2D6 (0.45) NOTUMKMT2AMEN1CHRM2CHRM4
SCHEMBL4782914 0.79 CHRM3 (0.43) KMT2AMEN1CHRM2CHRM4CHRM5
SCHEMBL4725202 0.78 SMN1; SMN2 (0.42) KMT2AMEN1CHRM2CHRM4CHRM5
SCHEMBL11826155 0.75 RORC (0.42) KMT2AMEN1CHRM2CHRM4CHRM5
SCHEMBL1846992 0.72 NOTUM (0.37) NOTUMKMT2ARAB9ANPC1CYP19A1
SCHEMBL3766102 0.70 L3MBTL1 (0.33) L3MBTL1
SCHEMBL4728205 0.70 CHRM3 (0.39) KMT2AMEN1CHRM2CHRM4CHRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008023157-A1 NITROGEN CONTAINING HETEROCYCLIC COMPOUNDS USEFUL AS M3-RECEPTOR MODULATORS ARGENTA DISCOVERY LIMITED (GB) 2008-02-28 WO disclosed
WO-2008023157-A1 NITROGEN CONTAINING HETEROCYCLIC COMPOUNDS USEFUL AS M3-RECEPTOR MODULATORS ARGENTA DISCOVERY LIMITED (GB) 2008-02-28 WO disclosed