⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3193152 | 0.76 | CES1 (0.54) | — | |
| Fluorene SCHEMBL29355380 | 0.76 | MAOA (0.68) | — | |
| Fluorene SCHEMBL29478468 | 0.76 | MAOA (0.68) | — | |
| Fluorene SCHEMBL545861 | 0.76 | MAOA (0.68) | — | |
| Fluorene SCHEMBL8180 | 0.76 | MAOA (0.68) | — | |
| Fluorene SCHEMBL31388525 | 0.76 | MAOA (0.68) | — | |
| Fluorene SCHEMBL28770483 | 0.74 | ALDH1A1 (0.60) | — | |
| Fluorene SCHEMBL5076892 | 0.74 | KDM4E (0.65) | — | |
| Fluorene SCHEMBL6009482 | 0.74 | KDM4E (0.65) | — | |
| Fluorene SCHEMBL1039293 | 0.73 | MAOA (0.65) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080318901-A1 | Novel Lysophosphatidic Acid Receptor Selective Antagonists | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2008-12-25 | — | — | US | claimed |
| EP-1750722-A2 | NOVEL LYSOPHOSPHATIDIC ACID RECEPTOR SELECTIVE ANTAGONISTS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2007-02-14 | — | — | EP | claimed |
| US-7169818-B2 | Lysophosphatidic acid receptor agonists and antagonists | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2007-01-30 | — | — | US | claimed |
| WO-2005115150-A2 | NOVEL LYSOPHOSPHATIDIC ACID RECEPTOR SELECTIVE ANTAGONISTS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2005-12-08 | — | — | WO | claimed |
| US-20050107447-A1 | Novel lysophosphatidic acid receptor agonists and antagonists | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-05-19 | — | — | US | claimed |
| US-20040122236-A1 | Novel lysophosphatidic acid receptor agonists and antagonists | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2004-06-24 | — | — | US | claimed |
| EP-1361872-A4 | NOVEL LYSOPHOSPHATIDIC ACID RECEPTOR AGONISTS AND ANTAGONISTS | UNIV VIRGINIA (US) | 2004-05-19 | — | — | EP | claimed |
| EP-1361872-A2 | NOVEL LYSOPHOSPHATIDIC ACID RECEPTOR AGONISTS AND ANTAGONISTS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2003-11-19 | — | — | EP | claimed |
| WO-2002029001-A2 | NOVEL LYSOPHOSPHATIDIC ACID RECEPTOR AGONISTS AND ANTAGONISTS | UNIVERSITY OF VIRGINIAN PATENT FOUNDATION (US) | 2002-04-11 | — | — | WO | claimed |