Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ACP3 | P15309 | 1/20 | 0.39 |
| ▸ | SCN4A | P35499 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.36 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.36 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17959290 | 1.00 | ESR1 (0.45) | ESR1KDM4ECYP1A2ACP3SCN4A | |
| SCHEMBL29746961 | 1.00 | ESR1 (0.45) | ESR1KDM4ECYP1A2ACP3SCN4A | |
| Hydrochloric Acid SCHEMBL19305459 | 0.98 | ESR1 (0.43) | ESR1KDM4ECYP1A2ACP3SCN4A | |
| Hydrochloric Acid SCHEMBL19305458 | 0.98 | ESR1 (0.43) | ESR1KDM4ECYP1A2ACP3SCN4A | |
| SCHEMBL29337470 | 0.83 | TRPA1 (0.40) | CYP1A2SCN4AALDH1A1TSHRMAOA | |
| SCHEMBL3383569 | 0.83 | ESR1 (0.42) | ESR1CYP1A2ACP3SCN4AALDH1A1 | |
| Hydrochloric Acid SCHEMBL382096 | 0.82 | ADRA2A (0.39) | CYP1A2SCN4AALDH1A1TSHRMAOA | |
| SCHEMBL3568608 | 0.82 | ALDH1A1 (0.48) | KDM4ECYP1A2SCN4AALDH1A1TSHR | |
| SCHEMBL7591099 | 0.80 | ESR1 (0.46) | ESR1SCN4AALDH1A1TSHRACHE | |
| SCHEMBL3865062 | 0.80 | ESR1 (0.46) | ESR1ACP3SCN4ATSHRACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114948963-B | Benzolactam compounds as protein kinase inhibitors | 大冢制药株式会社 | 2025-05-27 | — | — | CN | disclosed |
| US-12264137-B2 | 3-aryl-4-amido-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors | VALO HEALTH, INC. (US) | 2025-04-01 | — | — | US | disclosed |
| US-20240368136-A1 | BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2024-11-07 | — | — | US | disclosed |
| EP-3365334-B1 | BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS | OTSUKA PHARMA CO LTD (JP) | 2024-07-17 | — | — | EP | disclosed |
| WO-2024118094-A1 | SYSTEM AND METHOD FOR PREVENTING ALOPECIA | FOLLEA INTERNATIONAL (US) | 2024-06-06 | — | — | WO | disclosed |
| US-11939321-B2 | Benzolactam compounds as protein kinase inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2024-03-26 | — | — | US | disclosed |
| US-20230019032-A1 | BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2023-01-19 | — | — | US | disclosed |
| US-11555017-B2 | Oxidation base derived from 1-hexyl-4,5-diaminopyrazole, composition containing same and use thereof in oxidation dyeing of keratin fibres | L'OREAL (FR) | 2023-01-17 | — | — | US | disclosed |
| CN-114948963-A | Protein kinase inhibitor benzolactam compounds | 大冢制药株式会社 | 2022-08-30 | — | — | CN | disclosed |
| US-20220204461-A1 | 3-ARYL-4-AMIDO-BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS | VALO HEALTH, INC. | 2022-06-30 | — | — | US | disclosed |
| EP-3217967-A1 | SYSTEM AND METHOD FOR PREVENTING ALOPECIA | Follea International (US) | 2017-09-20 | — | — | EP | disclosed |
| WO-2017068412-A1 | BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2017-04-27 | — | — | WO | disclosed |
| WO-2016126724-A1 | 3-ARYL-4-AMIDO-BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2016-08-11 | — | — | WO | disclosed |
| US-20160222022-A1 | 3-ARYL-4-AMIDO-BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS | VALO HEALTH, INC. | 2016-08-04 | — | — | US | disclosed |
| WO-2016077744-A1 | SYSTEM AND METHOD FOR PREVENTING ALOPECIA | GOREN OFER A (US) | 2016-05-19 | — | — | WO | disclosed |
| WO-2008024634-A1 | PYRIMDINE COMPOUNDS USEFUL AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-28 | — | — | WO | disclosed |
| EP-1073511-A4 | POLYMERIC DIFUNCTIONAL CATIONIC EMOLLIENTS AND CONDITIONERS FOR USE IN COSMETIC, PERSONAL CARE AND HOUSEHOLD PRODUCTS | ALZO INC (US) | 2005-08-03 | — | — | EP | disclosed |
| EP-1073511-A1 | POLYMERIC DIFUNCTIONAL CATIONIC EMOLLIENTS AND CONDITIONERS FOR USE IN COSMETIC, PERSONAL CARE AND HOUSEHOLD PRODUCTS | Alzo, Inc. (US) | 2001-02-07 | — | — | EP | disclosed |
| US-6107352-A | CLEANING COMPOUNDS; COSMETICS | ALZO, INC. (US) | 2000-08-22 | — | — | US | disclosed |
| WO-1999054027-A1 | POLYMERIC DIFUNCTIONAL CATIONIC EMOLLIENTS AND CONDITIONERS FOR USE IN COSMETIC, PERSONAL CARE AND HOUSEHOLD PRODUCTS | ALZO, INC. (US) | 1999-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11939321-B2 | Benzolactam compounds as protein kinase inhibitors | MAPK1, ALK, MAP3K1 | ESR1 1975/4885KDM4E 1101/4885CYP1A2 1393/4885 |
| US-20160222022-A1 | 3-ARYL-4-AMIDO-BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS | HDAC1, HDAC4, HDAC2 | ESR1 4123/4885KDM4E 246/4885CYP1A2 2979/4885 |
| US-20230019032-A1 | BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS | MAPK1, ALK, MAP3K1 | ESR1 1975/4885KDM4E 1101/4885CYP1A2 1393/4885 |
| US-12264137-B2 | 3-aryl-4-amido-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors | HDAC1, HDAC4, HDAC2 | ESR1 4123/4885KDM4E 246/4885CYP1A2 2979/4885 |
| US-20220204461-A1 | 3-ARYL-4-AMIDO-BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS | HDAC1, HDAC4, HDAC2 | ESR1 4123/4885KDM4E 246/4885CYP1A2 2979/4885 |
| US-20240368136-A1 | BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS | MAPK1, ALK, MAP3K1 | ESR1 1958/4885KDM4E 1095/4885CYP1A2 1397/4885 |
| US-11555017-B2 | Oxidation base derived from 1-hexyl-4,5-diaminopyrazole, composition containing same and use thereof in oxidation dyeing of keratin fibres | KRT18, ALK, AOC1 | ESR1 3986/4885KDM4E 864/4885CYP1A2 922/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.