Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 14/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.63 |
| ▸ | DPP4 | P27487 | 1/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29552558 | 1.00 | SLC6A3 (0.63) | SLC6A3SLC6A4DPP4SLC6A2MAOA | |
| SCHEMBL4742182 | 0.98 | SLC6A3 (0.66) | SLC6A3SLC6A4DPP4SLC6A2MAOA | |
| SCHEMBL4807847 | 0.96 | SLC6A3 (0.58) | SLC6A3SLC6A4DPP4SLC6A2MAOA | |
| SCHEMBL4925293 | 0.93 | MAOA (0.59) | SLC6A3SLC6A4DPP4SLC6A2MAOA | |
| SCHEMBL13344069 | 0.85 | SLC6A4 (0.46) | SLC6A3SLC6A4DPP4SLC6A2MAOA | |
| SCHEMBL2225745 | 0.85 | PRKACA (0.52) | SLC6A3SLC6A4DPP4SLC6A2MAOA | |
| Hydrochloric Acid SCHEMBL3493099 | 0.83 | SLC6A4 (0.45) | SLC6A3SLC6A4DPP4SLC6A2MAOA | |
| SCHEMBL14004410 | 0.81 | ALDH1A1 (0.48) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL27167132 | 0.81 | SLC6A4 (0.41) | SLC6A3SLC6A4DPP4SLC6A2MAOA | |
| SCHEMBL30968661 | 0.79 | SLC6A4 (0.42) | SLC6A3SLC6A4DPP4SLC6A2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109268-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | DENALI THERAPEUTICS INC. (US) | 2022-05-27 | — | — | WO | disclosed |
| WO-2008063114-A9 | AMINO- IMIDAZOLONES AND THEIR USE AS MEDICAMENT FOR TREATING COGNITIVE IMPAIRMENT ALZHEIMER DISEASE, NEURODEGENERATION AND DEMENTIA | ASTRAZENECA AB (SE) | 2008-09-04 | — | — | WO | disclosed |
| WO-2008063114-A1 | AMINO- IMIDAZOLONES AND THEIR USE AS MEDICAMENT FOR TREATING COGNITIVE IMPAIRMENT ALZHEIMER DISEASE, NEURODEGENERATION AND DEMENTIA | ASTRAZENECA AB (SE) | 2008-05-29 | — | — | WO | disclosed |