SCHEMBL4780587

SCHEMBL4780587

CCCCOC(=O)n1[c]ccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 5/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
POLB P06746 1/20 0.44
BCHE P06276 1/20 0.42
ALDH1A1 P00352 3/20 0.41
TSHR P16473 6/20 0.41
TDP1 Q9NUW8 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
CYP1A2 P05177 2/20 0.39
CYP2C19 P33261 2/20 0.39
MAPK1 P28482 2/20 0.39
ESR1 P03372 2/20 0.39
CYP2D6 P10635 1/20 0.39
NR1H2 P55055 1/20 0.39
RNASEL Q05823 1/20 0.39
ATM Q13315 1/20 0.39
CYP3A4 P08684 2/20 0.38
CYP2C9 P11712 1/20 0.38
PDE4D Q08499 1/20 0.38
KMT2A Q03164 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4366139 0.73 ALDH1A1 (0.48) LMNASMN1; SMN2POLBBCHEALDH1A1
SCHEMBL2421520 0.72 LMNA (0.43) LMNASMN1; SMN2POLBBCHEALDH1A1
SCHEMBL3634052 0.69 SMN1; SMN2 (0.69) LMNASMN1; SMN2POLBBCHEALDH1A1
SCHEMBL1859157 0.69 SMN1; SMN2 (0.69) LMNASMN1; SMN2POLBALDH1A1TSHR
SCHEMBL9405372 0.69 POLB (0.73) LMNASMN1; SMN2POLBALDH1A1TSHR
SCHEMBL28810272 0.68 TSHR (0.49) LMNASMN1; SMN2POLBBCHEALDH1A1
SCHEMBL1826048 0.68 SMN1; SMN2 (0.67) LMNASMN1; SMN2POLBALDH1A1TDP1
SCHEMBL11492059 0.68 SMN1; SMN2 (0.67) LMNASMN1; SMN2POLBALDH1A1TDP1
SCHEMBL7838421 0.68 SMN1; SMN2 (0.67) LMNASMN1; SMN2POLBALDH1A1TDP1
Methyl Alcohol SCHEMBL27443089 0.68 SMN1; SMN2 (0.67) LMNASMN1; SMN2POLBBCHEALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104870445-A NOVEL DIHYDROPYRIMIDINOISOQUINOLINONES AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS (GPR84 ANTAGONISTS) GALAPAGOS NV 2015-08-26 CN disclosed
WO-2008009078-A2 4,6-DL- AND 2,4,6-TRISUBSTITUTED QUINAZOLINE DERIVATIVES USEFUL FOR TREATING VIRAL INFECTIONS GILEAD SCIENCES, INC. (US) 2008-01-24 WO disclosed
EP-1173206-A1 CONTRACEPTIVE COMPOSITIONS CONTAINING QUINAZOLINONE AND BENZOXAZINE DERIVATIVES American Home Products Corporation (US) 2002-01-23 EP disclosed
WO-2000066165-A1 CONTRACEPTIVE COMPOSITIONS CONTAINING QUINAZOLINONE AND BENZOXAZINE DERIVATIVES AMERICAN HOME PRODUCTS CORPORATION (US) 2000-11-09 WO disclosed