Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL854583 | 0.83 | NOTUM (0.54) | NOTUMMAPTKMT2AMEN1CASP3 | |
| SCHEMBL27973172 | 0.82 | KMT2A (0.50) | CES2CES1MAPTKMT2AMEN1 | |
| SCHEMBL10437093 | 0.82 | CES2 (0.59) | CES2CES1MAOAMAOBKMT2A | |
| SCHEMBL2175971 | 0.80 | CA12 (0.59) | PIM1HDAC1HDAC6MAOAMAPT | |
| SCHEMBL4024106 | 0.79 | HTR7 (0.46) | PIM1HDAC1HDAC6CES2CES1 | |
| SCHEMBL193625 | 0.79 | PIM1 (0.46) | PIM1HDAC1HDAC6CES2CES1 | |
| SCHEMBL4355959 | 0.78 | SMN1; SMN2 (0.53) | PIM1HDAC1HDAC6CES2CES1 | |
| SCHEMBL5674062 | 0.78 | MAPT (0.47) | HDAC1MAOAMAPTKMT2ACASP3 | |
| SCHEMBL29113751 | 0.76 | CA12 (0.42) | MAOAMAPTKMT2AMEN1RAB9A | |
| SCHEMBL1924482 | 0.76 | PIM1 (0.47) | PIM1HDAC1HDAC6CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008006044-A2 | SUBSTITUTED ACID DERIVATIVES USEFUL AS ANTIDIABETIC AND ANTIOBESITY AGENTS AND METHOD | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-01-10 | — | — | WO | disclosed |