Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4778049 | 0.96 | LMNA (0.44) | LMNAGLAL3MBTL1TSHRKDM4E | |
| SCHEMBL4781548 | 0.96 | LMNA (0.44) | LMNAGLAL3MBTL1TSHRKDM4E | |
| SCHEMBL4773925 | 0.92 | POLB (0.42) | LMNAGLAL3MBTL1TSHRKDM4E | |
| SCHEMBL4780527 | 0.92 | SMN1; SMN2 (0.42) | LMNAGLAL3MBTL1TSHRKDM4E | |
| SCHEMBL4780556 | 0.92 | KDM4E (0.46) | LMNAGLAL3MBTL1TSHRKDM4E | |
| SCHEMBL4779433 | 0.88 | PTGDR2 (0.50) | TSHRKDM4EPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL4778231 | 0.88 | KDM4E (0.46) | L3MBTL1TSHRKDM4EPOLBSMN1; SMN2 | |
| SCHEMBL4778810 | 0.86 | KDM4E (0.46) | L3MBTL1TSHRKDM4EPOLBSMN1; SMN2 | |
| SCHEMBL4776203 | 0.86 | KDM4E (0.46) | L3MBTL1TSHRKDM4EPOLBSMN1; SMN2 | |
| SCHEMBL4774108 | 0.86 | KDM4E (0.44) | L3MBTL1TSHRKDM4EPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009078-A2 | 4,6-DL- AND 2,4,6-TRISUBSTITUTED QUINAZOLINE DERIVATIVES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-01-24 | — | — | WO | claimed |
| WO-2008000818-A1 | FLUORINATED INDOLEAMIDES USEFUL AS LIGANDS OF THE ORL-1 RECEPTOR | BRANE DISCOVERY S.R.L. (IT) | 2008-01-03 | — | — | WO | disclosed |