Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | EBP | Q15125 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.37 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 8/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781020 | 1.00 | KMT2A (0.58) | KMT2ASIGMAR1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL11244923 | 0.84 | KMT2A (0.59) | KMT2AMEN1ALOX15P2RX7IMPDH2 | |
| SCHEMBL2086875 | 0.83 | KMT2A (0.56) | KMT2ASIGMAR1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL2086872 | 0.83 | KMT2A (0.56) | KMT2ASIGMAR1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL11174716 | 0.82 | KMT2A (0.58) | KMT2ASIGMAR1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL9954599 | 0.80 | KMT2A (0.56) | KMT2AMEN1ALOX15TSHRESR1 | |
| SCHEMBL9954596 | 0.80 | KMT2A (0.56) | KMT2AMEN1ALOX15TSHRESR1 | |
| SCHEMBL11265660 | 0.80 | KMT2A (0.52) | KMT2AMEN1ALOX15CXCR2 | |
| SCHEMBL3402743 | 0.80 | KMT2A (0.80) | KMT2ASIGMAR1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL2087129 | 0.80 | KMT2A (0.80) | KMT2ASIGMAR1GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080076924-A1 | Piperazines as P2X7 antagonists | ABBOTT LABORATORIES | 2008-03-27 | — | — | US | disclosed |
| WO-2008005368-A2 | PIPERAZINES AS P2X7 ANTAGONISTS | ABBOTT LABORATORIES (US) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076924-A1 | Piperazines as P2X7 antagonists | P2RX7, P2RX1, P2RX2 | KMT2A 3643/4885SIGMAR1 256/4885GRIN2D 702/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.