Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.54 |
| ▸ | CASP6 | P55212 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | ACLY | P53396 | 1/20 | 0.51 |
| ▸ | KDM1A | O60341 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30262500 | 0.90 | ERAP1 (0.70) | ALDH1A1LMNASMN1; SMN2MAPTKDM4E | |
| SCHEMBL4781525 | 0.80 | ALDH1A1 (1.00) | ALDH1A1LMNASMN1; SMN2MAPTKDM4E | |
| SCHEMBL30262514 | 0.79 | ERAP1 (0.69) | ALDH1A1LMNASMN1; SMN2MAPTKDM4E | |
| SCHEMBL5111331 | 0.78 | LMNA (0.62) | ALDH1A1LMNASMN1; SMN2MAPTKDM4E | |
| SCHEMBL4782068 | 0.78 | ALDH1A1 (0.83) | ALDH1A1LMNASMN1; SMN2MAPTKDM4E | |
| SCHEMBL3822813 | 0.74 | ALDH1A1 (0.61) | ALDH1A1LMNASMN1; SMN2KDM4EGAA | |
| SCHEMBL20357282 | 0.73 | ALDH1A1 (0.79) | ALDH1A1LMNASMN1; SMN2KDM4EHTT | |
| SCHEMBL30262537 | 0.73 | ERAP1 (0.83) | ALDH1A1LMNASMN1; SMN2ERAP1MCOLN3 | |
| SCHEMBL23119482 | 0.73 | LMNA (0.72) | ALDH1A1LMNASMN1; SMN2MAPTKDM4E | |
| SCHEMBL30262529 | 0.73 | ERAP1 (1.00) | ALDH1A1LMNASMN1; SMN2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | claimed |
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |