Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.83 |
| ▸ | LMNA | P02545 | 5/20 | 0.83 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.66 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.49 |
| ▸ | CASP6 | P55212 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781525 | 0.91 | ALDH1A1 (1.00) | ALDH1A1LMNASMN1; SMN2KDM4EMAPT | |
| SCHEMBL23119482 | 0.80 | LMNA (0.72) | ALDH1A1LMNASMN1; SMN2KDM4EMAPT | |
| SCHEMBL4781376 | 0.78 | ALDH1A1 (0.68) | ALDH1A1LMNASMN1; SMN2KDM4EMAPT | |
| SCHEMBL3486176 | 0.76 | LMNA (0.80) | ALDH1A1LMNASMN1; SMN2KDM4EMAPT | |
| SCHEMBL30262514 | 0.73 | ERAP1 (0.69) | ALDH1A1LMNASMN1; SMN2KDM4EMAPT | |
| SCHEMBL31587763 | 0.73 | ERAP1 (0.66) | ALDH1A1LMNASMN1; SMN2KDM4EMAPT | |
| SCHEMBL23851169 | 0.73 | ERAP1 (0.66) | ALDH1A1LMNASMN1; SMN2KDM4EMAPT | |
| SCHEMBL13006748 | 0.73 | ALDH1A1 (0.70) | ALDH1A1LMNASMN1; SMN2KDM4EMCOLN3 | |
| SCHEMBL10104444 | 0.72 | ALDH1A1 (0.69) | ALDH1A1LMNASMN1; SMN2KDM4EMCOLN3 | |
| SCHEMBL20657481 | 0.72 | TP53 (0.67) | ALDH1A1LMNASMN1; SMN2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | claimed |
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |